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Cell Growth & Differentiation Vol. 12, 363-369, July 2001
© 2001 American Association for Cancer Research

Phosphatidylinositol 3-Kinase Signaling Controls Levels of Hypoxia-inducible Factor 11

Bing-Hua Jiang2, Guoqiang Jiang3, Jenny Z. Zheng, Zhimin Lu4, Tony Hunter5 and Peter K. Vogt6

Department of Molecular and Experimental Medicine, BCC239, The Scripps Research Institute [B-H. J., J. Z. Z., P. K. V.], and Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies [G. J., Z. L., T. H.], La Jolla, California 92037

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has inherent oncogenic potential. It is up-regulated in diverse human cancers by either a gain of function in PI3K itself or in its downstream target Akt or by a loss of function in the negative regulator PTEN. However, the complete consequences of this up-regulation are not known. Here we show that insulin and epidermal growth factor or an inactivating mutation in the tumor suppressor PTEN specifically increase the protein levels of hypoxia-inducible factor (HIF) 1{alpha} but not of HIF-1ß in human cancer cell lines. This specific elevation of HIF-1{alpha} protein expression requires PI3K signaling. In the prostate carcinoma-derived cell lines PC-3 and DU145, insulin- and epidermal growth factor-induced expression of HIF-1{alpha} was inhibited by the PI3K-specific inhibitors LY294002 and wortmannin in a dose-dependent manner. HIF-1ß expression was not affected by these inhibitors. Introduction of wild-type PTEN into the PTEN-negative PC-3 cell line specifically inhibited the expression of HIF-1{alpha} but not that of HIF-1ß. In contrast to the HIF-1{alpha} protein, the level of HIF-1{alpha} mRNA was not significantly affected by PI3K signaling. Vascular endothelial growth factor reporter gene activity was induced by insulin in PC-3 cells and was inhibited by the PI3K inhibitor LY294002 and by the coexpression of a HIF-1 dominant negative construct. Vascular endothelial growth factor reporter gene activity was also inhibited by expression of a dominant negative PI3K construct and by the tumor suppressor PTEN.




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[Abstract] [Full Text] [PDF]


Home page
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Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model
Mol. Cancer Ther., November 1, 2007; 6(11): 2900 - 2908.
[Abstract] [Full Text] [PDF]


Home page
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J. J. Lum, T. Bui, M. Gruber, J. D. Gordan, R. J. DeBerardinis, K. L. Covello, M. C. Simon, and C. B. Thompson
The transcription factor HIF-1{alpha} plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
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[Abstract] [Full Text] [PDF]


Home page
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Chrysin inhibits expression of hypoxia-inducible factor-1{alpha} through reducing hypoxia-inducible factor-1{alpha} stability and inhibiting its protein synthesis
Mol. Cancer Ther., January 1, 2007; 6(1): 220 - 226.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
H. Tanaka, M. Yamamoto, N. Hashimoto, M. Miyakoshi, S. Tamakawa, M. Yoshie, Y. Tokusashi, K. Yokoyama, Y. Yaginuma, and K. Ogawa
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Cancer Res., December 1, 2006; 66(23): 11263 - 11270.
[Abstract] [Full Text] [PDF]


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IOVSHome page
Q. Ebrahem, A. Minamoto, G. Hoppe, B. Anand-Apte, and J. E. Sears
Triamcinolone Acetonide Inhibits IL-6- and VEGF-Induced Angiogenesis Downstream of the IL-6 and VEGF Receptors
, November 1, 2006; 47(11): 4935 - 4941.
[Abstract] [Full Text] [PDF]


Home page
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X.-H. Peng, P. Karna, Z. Cao, B.-H. Jiang, M. Zhou, and L. Yang
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J. Biol. Chem., September 8, 2006; 281(36): 25903 - 25914.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
K S Kimbro and J W Simons
Hypoxia-inducible factor-1 in human breast and prostate cancer.
Endocr. Relat. Cancer, September 1, 2006; 13(3): 739 - 749.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
V. H. Haase
Hypoxia-inducible factors in the kidney
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F271 - F281.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
N. Pore, Z. Jiang, H.-K. Shu, E. Bernhard, G. D. Kao, and A. Maity
Akt1 Activation Can Augment Hypoxia-Inducible Factor-1{alpha} Expression by Increasing Protein Translation through a Mammalian Target of Rapamycin-Independent Pathway
Mol. Cancer Res., July 1, 2006; 4(7): 471 - 479.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
P.A. Elustondo, G.E. Hannigan, I. Caniggia, and D.J. MacPhee
Integrin-Linked Kinase (ILK) Is Highly Expressed in First Trimester Human Chorionic Villi and Regulates Migration of a Human Cytotrophoblast-Derived Cell Line
Biol Reprod, May 1, 2006; 74(5): 959 - 968.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
J. Ding, J. Li, J. Chen, H. Chen, W. Ouyang, R. Zhang, C. Xue, D. Zhang, S. Amin, D. Desai, et al.
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J. Biol. Chem., April 7, 2006; 281(14): 9093 - 9100.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
N. Pore, Z. Jiang, A. Gupta, G. Cerniglia, G. D. Kao, and A. Maity
EGFR Tyrosine Kinase Inhibitors Decrease VEGF Expression by Both Hypoxia-Inducible Factor (HIF)-1-Independent and HIF-1-Dependent Mechanisms
Cancer Res., March 15, 2006; 66(6): 3197 - 3204.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. T. Dang, F. Chen, L. B. Gardner, J. M. Cummins, C. Rago, F. Bunz, S. V. Kantsevoy, and L. H. Dang
Hypoxia-Inducible Factor-1{alpha} Promotes Nonhypoxia-Mediated Proliferation in Colon Cancer Cells and Xenografts
Cancer Res., February 1, 2006; 66(3): 1684 - 1693.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
A. Dekanty, S. Lavista-Llanos, M. Irisarri, S. Oldham, and P. Wappner
The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-{alpha}/Sima
J. Cell Sci., December 1, 2005; 118(23): 5431 - 5441.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
A. K. Neumann, J. Yang, M. P. Biju, S. K. Joseph, R. S. Johnson, V. H. Haase, B. D. Freedman, and L. A. Turka
Hypoxia inducible factor 1{alpha} regulates T cell receptor signal transduction
PNAS, November 22, 2005; 102(47): 17071 - 17076.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
L. Hu, J. Hofmann, and R. B. Jaffe
Phosphatidylinostol 3-Kinase Mediates Angiogenesis and Vascular Permeability Associated with Ovarian Carcinoma
Clin. Cancer Res., November 15, 2005; 11(22): 8208 - 8212.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
H. Dalwadi, K. Krysan, N. Heuze-Vourc'h, M. Dohadwala, D. Elashoff, S. Sharma, N. Cacalano, A. Lichtenstein, and S. Dubinett
Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non-Small Cell Lung Cancer
Clin. Cancer Res., November 1, 2005; 11(21): 7674 - 7682.
[Abstract] [Full Text] [PDF]


Home page
Sci SignalHome page
R. H. Wenger, D. P. Stiehl, and G. Camenisch
Integration of Oxygen Signaling at the Consensus HRE
Sci. Signal., October 18, 2005; 2005(306): re12 - re12.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
Q. Zhang, X. Tang, Q. Y. Lu, Z. F. Zhang, J. Brown, and A. D. Le
Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1{alpha} and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
Mol. Cancer Ther., October 1, 2005; 4(10): 1465 - 1474.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
M. L. Yen, J. L. Su, C. L. Chien, K. W. Tseng, C. Y. Yang, W. F. Chen, C. C. Chang, and M. L. Kuo
Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt and p38 Mitogen-Activated Protein Kinase Pathways in Osteoblasts
Mol. Pharmacol., October 1, 2005; 68(4): 1061 - 1073.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
L.-Z. Liu, J. Fang, Q. Zhou, X. Hu, X. Shi, and B.-H. Jiang
Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer
Mol. Pharmacol., September 1, 2005; 68(3): 635 - 643.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
G. J. Kelloff, J. M. Hoffman, B. Johnson, H. I. Scher, B. A. Siegel, E. Y. Cheng, B. D. Cheson, J. O'Shaughnessy, K. Z. Guyton, D. A. Mankoff, et al.
Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development
Clin. Cancer Res., April 15, 2005; 11(8): 2785 - 2808.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
J. Fang, C. Xia, Z. Cao, J. Z. Zheng, E. Reed, and B.-H. Jiang
Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
FASEB J, March 1, 2005; 19(3): 342 - 353.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
R. Blum, J. Jacob-Hirsch, N. Amariglio, G. Rechavi, and Y. Kloog
Ras Inhibition in Glioblastoma Down-regulates Hypoxia-Inducible Factor-1{alpha}, Causing Glycolysis Shutdown and Cell Death
Cancer Res., February 1, 2005; 65(3): 999 - 1006.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
E. V. Gerasimovskaya, D. A. Tucker, and K. R. Stenmark
Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation
J Appl Physiol, February 1, 2005; 98(2): 722 - 731.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M.-H. Li, Z.-H. Miao, W.-F. Tan, J.-M. Yue, C. Zhang, L.-P. Lin, X.-W. Zhang, and J. Ding
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Clin. Cancer Res., December 15, 2004; 10(24): 8266 - 8274.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
G. J. Hutchison, H. R. Valentine, J. A. Loncaster, S. E. Davidson, R. D. Hunter, S. A. Roberts, A. L. Harris, I. J. Stratford, P. M. Price, and C. M. L. West
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Home page
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J. Biol. Chem., October 29, 2004; 279(44): 45643 - 45651.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. Z. Qian, X. Wang, S. K. Kachhap, Y. Kato, Y. Wei, L. Zhang, P. Atadja, and R. Pili
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Home page
Mol. Pharmacol.Home page
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Mol. Pharmacol., September 1, 2004; 66(3): 612 - 619.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
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[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
J. Fang, Z. Cao, Y. C. Chen, E. Reed, and B.-H. Jiang
9-{beta}-D-Arabinofuranosyl-2-fluoroadenine Inhibits Expression of Vascular Endothelial Growth Factor through Hypoxia-Inducible Factor-1 in Human Ovarian Cancer Cells
Mol. Pharmacol., July 1, 2004; 66(1): 178 - 186.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
G. Powis and L. Kirkpatrick
Hypoxia inducible factor-1{alpha} as a cancer drug target
Mol. Cancer Ther., May 1, 2004; 3(5): 647 - 654.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
L. Bemis, D. A. Chan, C. V. Finkielstein, L. Qi, P. D. Sutphin, X. Chen, K. Stenmark, A. J. Giaccia, and W. Zundel
Distinct aerobic and hypoxic mechanisms of HIF-{alpha} regulation by CSN5
Genes & Dev., April 1, 2004; 18(7): 739 - 744.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Höpfl, O. Ogunshola, and M. Gassmann
HIFs and tumors--causes and consequences
Am J Physiol Regulatory Integrative Comp Physiol, March 5, 2004; 286(4): R608 - R623.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
U. Roth, K. Curth, T. G. Unterman, and T. Kietzmann
The Transcription Factors HIF-1 and HNF-4 and the Coactivator p300 Are Involved in Insulin-regulated Glucokinase Gene Expression via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
J. Biol. Chem., January 23, 2004; 279(4): 2623 - 2631.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
J. Li, G. Davidson, Y. Huang, B.-H. Jiang, X. Shi, M. Costa, and C. Huang
Nickel Compounds Act through Phosphatidylinositol-3-kinase/Akt-Dependent, p70S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and Cap43 Expression in Mouse Epidermal Cl41 Cells
Cancer Res., January 1, 2004; 64(1): 94 - 101.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
T. T.-L. Tang and L. A. Lasky
The Forkhead Transcription Factor FOXO4 Induces the Down-regulation of Hypoxia-inducible Factor 1{alpha} by a von Hippel-Lindau Protein-independent Mechanism
J. Biol. Chem., August 8, 2003; 278(32): 30125 - 30135.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
D. C. Lev, M. Ruiz, L. Mills, E. C. McGary, J. E. Price, and M. Bar-Eli
Dacarbazine Causes Transcriptional Up-Regulation of Interleukin 8 and Vascular Endothelial Growth Factor in Melanoma Cells: A Possible Escape Mechanism from Chemotherapy
Mol. Cancer Ther., August 1, 2003; 2(8): 753 - 763.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
L. Zhang, N. Yang, D. Katsaros, W. Huang, J.-W. Park, S. Fracchioli, C. Vezzani, I. A. Rigault de la Longrais, W. Yao, S. C. Rubin, et al.
The Oncogene Phosphatidylinositol 3'-Kinase Catalytic Subunit {alpha} Promotes Angiogenesis via Vascular Endothelial Growth Factor in Ovarian Carcinoma
Cancer Res., July 15, 2003; 63(14): 4225 - 4231.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
N. J. Mabjeesh, M. T. Willard, C. E. Frederickson, H. Zhong, and J. W. Simons
Androgens Stimulate Hypoxia-inducible Factor 1 Activation via Autocrine Loop of Tyrosine Kinase Receptor/Phosphatidylinositol 3'-Kinase/Protein Kinase B in Prostate Cancer Cells
Clin. Cancer Res., July 1, 2003; 9(7): 2416 - 2425.
[Abstract] [Full Text] [PDF]


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J. Cell Sci.Home page
S. Turcotte, R. R. Desrosiers, and R. Beliveau
HIF-1{alpha} mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma
J. Cell Sci., June 1, 2003; 116(11): 2247 - 2260.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
S. J. Welsh, R. R. Williams, A. Birmingham, D. J. Newman, D. L. Kirkpatrick, and G. Powis
The Thioredoxin Redox Inhibitors 1-Methylpropyl 2-Imidazolyl Disulfide and Pleurotin Inhibit Hypoxia-induced Factor 1{alpha} and Vascular Endothelial Growth Factor Formation
Mol. Cancer Ther., March 1, 2003; 2(3): 235 - 243.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
M. C. A. Duyndam, S. T. M. Hulscher, E. van der Wall, H. M. Pinedo, and E. Boven
Evidence for a Role of p38 Kinase in Hypoxia-inducible Factor 1-independent Induction of Vascular Endothelial Growth Factor Expression by Sodium Arsenite
J. Biol. Chem., February 28, 2003; 278(9): 6885 - 6895.
[Abstract] [Full Text] [PDF]


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Mol Cancer ResHome page
K. D. Burroughs, J. Oh, J. C. Barrett, and R. P. DiAugustine
Phosphatidylinositol 3-Kinase and Mek1/2 Are Necessary for Insulin-Like Growth Factor-I-Induced Vascular Endothelial Growth Factor Synthesis in Prostate Epithelial Cells: A Role for Hypoxia-Inducible Factor-1?
Mol. Cancer Res., February 1, 2003; 1(4): 312 - 322.
[Abstract] [Full Text] [PDF]


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BloodHome page
T. Kietzmann, A. Samoylenko, U. Roth, and K. Jungermann
Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes
Blood, February 1, 2003; 101(3): 907 - 914.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
N. Gao, B.-H. Jiang, S. S. Leonard, L. Corum, Z. Zhang, J. R. Roberts, J. Antonini, J. Z. Zheng, D. C. Flynn, V. Castranova, et al.
p38 Signaling-mediated Hypoxia-inducible Factor 1{alpha} and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells
J. Biol. Chem., November 22, 2002; 277(47): 45041 - 45048.
[Abstract] [Full Text] [PDF]


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Mol. Cell. Biol.Home page
C. C. Hudson, M. Liu, G. G. Chiang, D. M. Otterness, D. C. Loomis, F. Kaper, A. J. Giaccia, and R. T. Abraham
Regulation of Hypoxia-Inducible Factor 1{alpha} Expression and Function by the Mammalian Target of Rapamycin
Mol. Cell. Biol., October 15, 2002; 22(20): 7004 - 7014.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
S. J. Welsh, W. T. Bellamy, M. M. Briehl, and G. Powis
The Redox Protein Thioredoxin-1 (Trx-1) Increases Hypoxia-inducible Factor 1{alpha} Protein Expression: Trx-1 Overexpression Results in Increased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis
Cancer Res., September 1, 2002; 62(17): 5089 - 5095.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
N. Gao, M. Ding, J. Z. Zheng, Z. Zhang, S. S. Leonard, K. J. Liu, X. Shi, and B.-H. Jiang
Vanadate-induced Expression of Hypoxia-inducible Factor 1{alpha} and Vascular Endothelial Growth Factor through Phosphatidylinositol 3-Kinase/Akt Pathway and Reactive Oxygen Species
J. Biol. Chem., August 30, 2002; 277(35): 31963 - 31971.
[Abstract] [Full Text] [PDF]


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Sci SignalHome page
K. A. Seta, Z. Spicer, Y. Yuan, G. Lu, and D. E. Millhorn
Responding to Hypoxia: Lessons From a Model Cell Line
Sci. Signal., August 20, 2002; 2002(146): re11 - re11.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
V. Seshadri, P. L. Fox, and C. K. Mukhopadhyay
Dual Role of Insulin in Transcriptional Regulation of the Acute Phase Reactant Ceruloplasmin
J. Biol. Chem., August 2, 2002; 277(31): 27903 - 27911.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
C. Treins, S. Giorgetti-Peraldi, J. Murdaca, G. L. Semenza, and E. Van Obberghen
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
J. Biol. Chem., August 2, 2002; 277(31): 27975 - 27981.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
S. Kaluz, M. Kaluzova, A. Chrastina, P. L. Olive, S. Pastorekova, J. Pastorek, M. I. Lerman, and E. J. Stanbridge
Lowered Oxygen Tension Induces Expression of the Hypoxia Marker MN/Carbonic Anhydrase IX in the Absence of Hypoxia-inducible Factor 1{alpha} Stabilization: A Role for Phosphatidylinositol 3'-Kinase
Cancer Res., August 1, 2002; 62(15): 4469 - 4477.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
A. M. Arsham, D. R. Plas, C. B. Thompson, and M. C. Simon
Phosphatidylinositol 3-Kinase/Akt Signaling Is Neither Required for Hypoxic Stabilization of HIF-1{alpha} nor Sufficient for HIF-1-dependent Target Gene Transcription
J. Biol. Chem., April 26, 2002; 277(17): 15162 - 15170.
[Abstract] [Full Text] [PDF]


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J Biol ChemHome page
M. Alvarez-Tejado, A. Alfranca, J. Aragones, A. Vara, M. O. Landazuri, and L. del Peso
Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension
J. Biol. Chem., April 19, 2002; 277(16): 13508 - 13517.
[Abstract] [Full Text] [PDF]




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