CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edlund, M.
Right arrow Articles by Chung, L. W. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edlund, M.
Right arrow Articles by Chung, L. W. K.
Cell Growth & Differentiation Vol. 12, 99-107, February 2001
© 2001 American Association for Cancer Research

Integrin Expression and Usage by Prostate Cancer Cell Lines on Laminin Substrata1

Magnus Edlund2, Tadayuki Miyamoto2, Robert A. Sikes, Roy Ogle, Gordon W. Laurie, Mary C. Farach-Carson, Carol A. Otey, Haiyen E. Zhau and Leland W. K. Chung3

Departments of Urology [M. E., T. M., R. A. S., H. E. Z., L. W. K. C.] and Cell Biology [R. O., G. W. L., L. W. K. C.], University of Virginia Health System, Charlottesville, Virginia 22908; Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7545 [C. A. O.]; and Department of Biological Sciences, University of Delaware, Newark, Delaware 19716 [M. C. F-C.]

During prostate cancer progression, invasive glandular epithelial cells move out of the ductal-acinar architecture and through the surrounding basement membrane. Extracellular matrix proteins and associated soluble factors in the basal lamina and underlying stroma are known to be important regulators of prostate cell behaviors in both normal and malignant tissues. In this study, we assessed cell interactions with extracellular matrix and stromal factors during disease progression by characterizing integrin usage and expression in a series of parental and lineage-derived LNCaP human prostate cancer cell lines. Although few shifts in integrin expression were found to accompany disease progression, integrin heterodimer usage did change significantly. The more metastatic sublines were distinct in their use of {alpha}vß3 and, when compared with parental LNCaP cells, showed a shift in {alpha}6 heterodimerization, a subunit critical not only for interaction with prostate basal lamina but also for interaction with the bone matrix, a favored site of prostate cancer metastases.




This article has been cited by other articles:


Home page
Anticancer ResHome page
K. LERTSUWAN, W. PETERS, L. JOHNSON, J. LERTSUWAN, I. MARWA, and R. A. SIKES
Purinergic Receptor Expression and Cellular Responses to Purinergic Agonists in Human Prostate Cancer Cells
Anticancer Res, February 1, 2017; 37(2): 529 - 537.
[Abstract] [Full Text] [PDF]


Home page
Biochem. J.Home page
A. Dutta, J. Li, C. Fedele, A. Sayeed, A. Singh, S. M. Violette, T. D. Manes, and L. R. Languino
{alpha}v{beta}6 integrin is required for TGF{beta}1-mediated matrix metalloproteinase2 expression
Biochem. J., March 15, 2015; 466(3): 525 - 536.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
X. Zhang, M. V. Fournier, J. L. Ware, M. J. Bissell, A. Yacoub, and Z. E. Zehner
Inhibition of vimentin or {beta}1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo
Mol. Cancer Ther., March 1, 2009; 8(3): 499 - 508.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. B. Meads, L. A. Hazlehurst, and W. S. Dalton
The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance
Clin. Cancer Res., May 1, 2008; 14(9): 2519 - 2526.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. J. Najy, K. C. Day, and M. L. Day
ADAM15 Supports Prostate Cancer Metastasis by Modulating Tumor Cell-Endothelial Cell Interaction
Cancer Res., February 15, 2008; 68(4): 1092 - 1099.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
L. Moro, A. A. Arbini, E. Marra, and M. Greco
Up-regulation of Skp2 after Prostate Cancer Cell Adhesion to Basement Membranes Results in BRCA2 Degradation and Cell Proliferation
J. Biol. Chem., August 4, 2006; 281(31): 22100 - 22107.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
S. De, J. Chen, N. V. Narizhneva, W. Heston, J. Brainard, E. H. Sage, and T. V. Byzova
Molecular Pathway for Cancer Metastasis to Bone
J. Biol. Chem., October 3, 2003; 278(40): 39044 - 39050.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. J. Sakko, C. Ricciardelli, K. Mayne, S. Suwiwat, R. G. LeBaron, V. R. Marshall, W. D. Tilley, and D. J. Horsfall
Modulation of Prostate Cancer Cell Attachment to Matrix by Versican
Cancer Res., August 15, 2003; 63(16): 4786 - 4791.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
W. P. Schiemann, G. C. Blobe, D. E. Kalume, A. Pandey, and H. F. Lodish
Context-specific Effects of Fibulin-5 (DANCE/EVEC) on Cell Proliferation, Motility, and Invasion: FIBULIN-5 IS INDUCED BY TRANSFORMING GROWTH FACTOR-{beta} AND AFFECTS PROTEIN KINASE CASCADES
J. Biol. Chem., July 26, 2002; 277(30): 27367 - 27377.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
B. Cinar, K. S. Koeneman, M. Edlund, G. S. Prins, H. E. Zhau, and L. W. K. Chung
Androgen Receptor Mediates the Reduced Tumor Growth, Enhanced Androgen Responsiveness, and Selected Target Gene Transactivation in a Human Prostate Cancer Cell Line
Cancer Res., October 1, 2001; 61(19): 7310 - 7317.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2001 by the American Association of Cancer Research.