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Departments of Urology [M. E., T. M., R. A. S., H. E. Z., L. W. K. C.] and Cell Biology [R. O., G. W. L., L. W. K. C.], University of Virginia Health System, Charlottesville, Virginia 22908; Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7545 [C. A. O.]; and Department of Biological Sciences, University of Delaware, Newark, Delaware 19716 [M. C. F-C.]
During prostate cancer progression, invasive glandular epithelial cells
move out of the ductal-acinar architecture and through the surrounding
basement membrane. Extracellular matrix proteins and associated soluble
factors in the basal lamina and underlying stroma are known to be
important regulators of prostate cell behaviors in both normal and
malignant tissues. In this study, we assessed cell interactions with
extracellular matrix and stromal factors during disease progression by
characterizing integrin usage and expression in a series of parental
and lineage-derived LNCaP human prostate cancer cell lines. Although
few shifts in integrin expression were found to accompany disease
progression, integrin heterodimer usage did change significantly. The
more metastatic sublines were distinct in their use of
vß3 and, when compared with parental LNCaP
cells, showed a shift in 6 heterodimerization, a subunit
critical not only for interaction with prostate basal lamina but also
for interaction with the bone matrix, a favored site of prostate cancer
metastases.
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