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Cell Growth & Differentiation Vol. 12, 497-504, October 2001
© 2001 American Association for Cancer Research

Characterization of Syndecan-4 Expression in 3T3-F442A Mouse Adipocytes

Link between Syndecan-4 Induction and Cell Proliferation1

Reiko Landry2, Vincent Rioux and André Bensadoun3

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853

Heparan sulfate proteoglycans are found on the surface of most cells. Syndecan-4 is a widely expressed transmembrane heparan sulfate proteoglycan. Using quantitative RNase protection assays and immunoblotting, syndecan-4 expression was characterized in 3T3-F442A mouse adipoblasts. These cells exhibit dramatic changes in their biological and morphological characteristics during differentiation to adipocytes. During this process, the levels of syndecan-4 protein and mRNA expression changed dramatically. They peaked at the time when quiescent cells reentered the cell cycle before differentiation. Serum depletion-repletion also replicated the syndecan-4 mRNA induction when the cells were released back into proliferation, and a cycloheximide treatment abolished the peak of induction. In addition, inhibiting syndecan-4 induction with antisense oligonucleotides inhibited the proliferation of 3T3-F442A cells. In the terminally differentiated adipocytes characterized by the loss of proliferation capability, the serum inducibility of syndecan-4 is repressed, emphasizing the link between syndecan-4 induction in 3T3-F442A cells and cell proliferation.




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S. Page, A. Judson, K. Melford, and A. Bensadoun
Interaction of Lipoprotein Lipase and Receptor-associated Protein
J. Biol. Chem., May 19, 2006; 281(20): 13931 - 13938.
[Abstract] [Full Text] [PDF]




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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2001 by the American Association of Cancer Research.