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Cell Growth & Differentiation Vol. 11, 527-539, October 2000
© 2000 American Association for Cancer Research


Articles

Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen1

Diana Escalante-Alcalde2, Felix Recillas-Targa2,3, Concepción Valencia, Jesús Santa-Olalla, Pedro Chávez, Alberto Marroquín, Lourdes Gutiérrez-X, Patricio Gariglio and Luis Covarrubias4

Departamento de Genética y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca Mor. 62250 [D. E-A., F. R-T., C. V., J. S-O., L. C.]; Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Mexico, D.F. 11500 [P. G., L. C.]; Departamento de Genética, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Mexico, D.F. 07360 [P. C., A. M., P. G.]; and Departamento de Virus y Cáncer, Instituto Nacional de Salud Pública, Cuernavaca, Mor. 62508 [L. G-X.], Mexico

Abstract

Hair follicle growth cycle proceeds through a series of stages in which strict control of cell proliferation, differentiation, and cell death occurs. Transgenic mice expressing human papillomavirus type 16 E6/E7 papillomavirus oncogenes in the outer root sheath (ORS) display a fur phenotype characterized by lower hair density and the ability to regenerate hair much faster than wild-type mice. Regenerating hair follicles of transgenic mice show a longer growth phase (anagen), and although bulb regression (catagen) occurs, rest at telogen was not observed. No abnormalities were detected during the first cycle of hair follicle growth, but by the second cycle, initiation of catagen was delayed, and rest at telogen was again not attained, even in the presence of estradiol, a telogen resting signal. In conclusion, expression of E6/E7 in the ORS delays entrance to catagen and makes cells of the ORS insensitive to telogen resting signals bearing to a continuous hair follicle cycling in transgenic mice.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2000 by the American Association of Cancer Research.