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Cell Growth & Differentiation Vol. 10, 583-590, August 1999
© 1999 American Association for Cancer Research

Influence of Prolactin on the Differentiation of Mouse B-Lymphoid Precursors1

Patricia Morales, María Victoria Carretero, Haydée Geronimo, Sergio G. Copín, María Luisa Gaspar, Miguel A. R. Marcos and Jorge Martín-Pérez2

Centro de Biología Molecular Severo Ochoa, C.S.I.C., Campus Cantoblanco, 28049 Madrid [P. M., S. G. C., M. A. R. M.]; Instituto de Investigaciones Biomédicas, C.S.I.C., Arturo Duperier 4, 28029 Madrid [M. V. C., H. G., J. M-P.]; Centro Nacional de Biología Fundamental, Instituto de Salud Carlos III, Majadahonda 28220, Madrid [M. L. G.], Spain

Development and activation of immune cells are submitted to hormonal influences, as illustrated by the roles of corticosteroids in thymus, pregnancy-related estrogens in B-cell development, or prolactin (PRL) on T-cell generation and function. We have analyzed the putative role of PRL in B lymphopoiesis and differentiation. We chose as an experimental model the interleukin (IL)-3 dependent BaF-3 pro-B cell line, which was transfected with the rat long form of the PRL receptor (PRL-R) and transferred from IL-3- to PRL-enriched media. When stimulated with PRL, the PRL-R transfectants underwent some changes characteristic of B-cell differentiation: (a) IL-2R {alpha} chain became positively controlled by PRL; (b) antiapoptotic Bcl-2 protein was induced by PRL in a dose-dependent manner; and (c) transcription of the pre-B cell receptor encoding the {lambda}5 gene was strongly up-regulated. We attempted to evaluate the differentiation-promoting activity of PRL in more physiological conditions, and the presence of PRL-R in bone marrow B-cell precursors was revealed. Furthermore, PRL promoted significant expansions of defined B-lineage cell populations in short-term bone marrow cell cultures. These findings suggest that PRL, in collaboration with other cytokines and hormonal influences, modulates B-cell development.




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J. Zhang, R. Sun, and Z. Tian
Human Prolactin Promotes Human Secondary Immunoglobulin Response in Human/SCID Mouse Chimeras
Clin. Vaccine Immunol., January 1, 2007; 14(1): 60 - 64.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1999 by the American Association of Cancer Research.