CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rodriguez-Puebla, M. L.
Right arrow Articles by Conti, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rodriguez-Puebla, M. L.
Right arrow Articles by Conti, C. J.
Cell Growth & Differentiation Vol. 10, 467-472, July 1999
© 1999 American Association for Cancer Research

Cyclin D1 Overexpression in Mouse Epidermis Increases Cyclin-dependent Kinase Activity and Cell Proliferation in Vivo but Does Not Affect Skin Tumor Development1

Marcelo L. Rodriguez-Puebla, Margaret LaCava and Claudio J. Conti2

The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957

In a previous study, we showed that synchronized proliferation of mouse epidermis was induced by topical application of 12-O-tetradecanoyl-phorbol 13-acetate. Here, we used this system to study modifications in the cell cycle regulation and kinetics of proliferation in transgenic mice that overexpress cyclin D1 (K5D1 mice). Overexpression of cyclin D1 corresponded with an increase of proliferation in the epidermis of these transgenic mice. After proliferation reached its peak, the labeling index remained high in the transgenics, but not in the wild-type animals. In addition, cyclin D1/cyclin-dependent kinase (CDK) complex formation increased in the transgenic mice and was correlated with elevated CDK4 and CDK6 kinase activities. However, the increased CDK activities were not sufficient to effect mouse skin tumor development. In summary, these results show that cyclin D1 has a unique growth-promoting role in tumor development, but does not act as an oncogene independent of ras activity.




This article has been cited by other articles:


Home page
Cancer Res.Home page
M. A. Patil, S. A. Lee, E. Macias, E. T. Lam, C. Xu, K. D. Jones, C. Ho, M. Rodriguez-Puebla, and X. Chen
Role of Cyclin D1 as a Mediator of c-Met- and {beta}-Catenin-Induced Hepatocarcinogenesis
Cancer Res., January 1, 2009; 69(1): 253 - 261.
[Abstract] [Full Text] [PDF]


Home page
Cancer Prev ResHome page
T. Moore, L. Beltran, S. Carbajal, S. Strom, J. Traag, S. D. Hursting, and J. DiGiovanni
Dietary Energy Balance Modulates Signaling through the Akt/Mammalian Target of Rapamycin Pathways in Multiple Epithelial Tissues
Cancer Prevention Research, June 1, 2008; 1(1): 65 - 76.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Garcia-Espana, E. Salazar, T.-T. Sun, X.-R. Wu, and A. Pellicer
Differential Expression of Cell Cycle Regulators in Phenotypic Variants of Transgenically Induced Bladder Tumors: Implications for Tumor Behavior
Cancer Res., February 15, 2005; 65(4): 1150 - 1157.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. S. Chan, S. Carbajal, K. Kiguchi, J. Clifford, S. Sano, and J. DiGiovanni
Epidermal Growth Factor Receptor-Mediated Activation of Stat3 during Multistage Skin Carcinogenesis
Cancer Res., April 1, 2004; 64(7): 2382 - 2389.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. Y. Y. Fong, R. Mancini, H. Nakagawa, A. K. Rustgi, and K. Huebner
Combined Cyclin D1 Overexpression and Zinc Deficiency Disrupts Cell Cycle and Accelerates Mouse Forestomach Carcinogenesis
Cancer Res., July 15, 2003; 63(14): 4244 - 4252.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
C. J. Nelsen, D. G. Rickheim, M. M. Tucker, L. K. Hansen, and J. H. Albrecht
Evidence That Cyclin D1 Mediates Both Growth and Proliferation Downstream of TOR in Hepatocytes
J. Biol. Chem., February 7, 2003; 278(6): 3656 - 3663.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
J. Reichelt and T. M. Magin
Hyperproliferation, induction of c-Myc and 14-3-3{sigma}, but no cell fragility in keratin-10-null mice
J. Cell Sci., July 1, 2002; 115(13): 2639 - 2650.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
H. Yamamoto, T. Ochiya, F. Takeshita, H. Toriyama-Baba, K. Hirai, H. Sasaki, H. Sasaki, H. Sakamoto, T. Yoshida, I. Saito, et al.
Enhanced Skin Carcinogenesis in Cyclin D1-conditional Transgenic Mice: Cyclin D1 Alters Keratinocyte Response to Calcium-induced Terminal Differentiation
Cancer Res., March 1, 2002; 62(6): 1641 - 1647.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. J. Nelsen, D. G. Rickheim, N. A. Timchenko, M. W. Stanley, and J. H. Albrecht
Transient Expression of Cyclin D1 Is Sufficient to Promote Hepatocyte Replication and Liver Growth in Vivo
Cancer Res., December 1, 2001; 61(23): 8564 - 8568.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
X. Xia, S. Qian, S. Soriano, Y. Wu, A. M. Fletcher, X.-J. Wang, E. H. Koo, X. Wu, and H. Zheng
Loss of presenilin 1 is associated with enhanced {beta}-catenin signaling and skin tumorigenesis
PNAS, September 11, 2001; 98(19): 10863 - 10868.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. A. Curran, F. S. Laverty, D. Campbell, J. Macdiarmid, and J. B. Wilson
Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Epithelial Cell Proliferation and Sensitizes Transgenic Mice to Chemical Carcinogenesis
Cancer Res., September 1, 2001; 61(18): 6730 - 6738.
[Abstract] [Full Text] [PDF]


Home page
EMBO J.Home page
S. A. Datar, H. W. Jacobs, A. F. A. de la Cruz, C. F. Lehner, and B. A. Edgar
The Drosophila Cyclin D-Cdk4 complex promotes cellular growth
EMBO J., September 1, 2000; 19(17): 4543 - 4554.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
X. Xia, S. Qian, S. Soriano, Y. Wu, A. M. Fletcher, X.-J. Wang, E. H. Koo, X. Wu, and H. Zheng
Loss of presenilin 1 is associated with enhanced {beta}-catenin signaling and skin tumorigenesis
PNAS, September 11, 2001; 98(19): 10863 - 10868.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1999 by the American Association of Cancer Research.