CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Besset, V.
Right arrow Articles by Wolgemuth, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Besset, V.
Right arrow Articles by Wolgemuth, D. J.
Cell Growth & Differentiation Vol. 10, 173-181, March 1999
© 1999 American Association for Cancer Research

The Cellular Distribution and Kinase Activity of the Cdk Family Member Pctaire1 in the Adult Mouse Brain and Testis Suggest Functions in Differentiation1

Valerie Besset, Kunsoo Rhee and Debra J. Wolgemuth2

Departments of Genetics and Development [V. B., K. R., D. J. W.], and Obstetrics and Gynecology [D. J. W.], Center for Reproductive Sciences [D. J. W.], The Irving Comprehensive Cancer Center [D. J. W.], and The Institute of Human Nutrition [D. J. W.], Columbia University College of Physicians and Surgeons, New York, New York 10032

Pctaire1, a member of the family of cyclin-dependent kinases, has been shown to be particularly abundantly expressed in differentiated tissues such as testis and brain. However, very little is known about the cellular and subcellular distribution and function of Pctaire1 protein(s), which is the focus of this study. We show that Pctaire1 encoded two major proteins of Mr {approx}62,000 and {approx}68,000, found predominantly in testis and brain. Within these two tissues, Pctaire1 was most abundant in the cytoplasm of terminally differentiated cells, notably, the pyramidal neurons in brain and elongated spermatids in testis. Immunoprecipitation experiments further showed that a kinase activity toward myelin basic protein was associated with Pctaire1 in the adult testis and brain and that its activity was potentially regulated through association with regulatory partner(s). These results suggest that Pctaire1 kinase might have an important role in differentiated cells such as postmitotic neurons and spermatogenic cells.




This article has been cited by other articles:


Home page
Mol. Cell. Biol.Home page
S. Iwano, A. Satou, S. Matsumura, N. Sugiyama, Y. Ishihama, and F. Toyoshima
PCTK1 Regulates Integrin-Dependent Spindle Orientation via Protein Kinase A Regulatory Subunit KAP0 and Myosin X
Mol. Cell. Biol., April 1, 2015; 35(7): 1197 - 1208.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
S. Lim and P. Kaldis
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Development, August 1, 2013; 140(15): 3079 - 3093.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
X.-Y. Chen, X.-T. Gu, H. Saiyin, B. Wan, Y.-J. Zhang, J. Li, Y.-L. Wang, R. Gao, Y.-F. Wang, W.-P. Dong, et al.
Brain-selective Kinase 2 (BRSK2) Phosphorylation on PCTAIRE1 Negatively Regulates Glucose-stimulated Insulin Secretion in Pancreatic {beta}-Cells
J. Biol. Chem., August 31, 2012; 287(36): 30368 - 30375.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
P. Mikolcevic, R. Sigl, V. Rauch, M. W. Hess, K. Pfaller, M. Barisic, L. J. Pelliniemi, M. Boesl, and S. Geley
Cyclin-Dependent Kinase 16/PCTAIRE Kinase 1 Is Activated by Cyclin Y and Is Essential for Spermatogenesis
Mol. Cell. Biol., February 15, 2012; 32(4): 868 - 879.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
M. H. Mokalled, A. Johnson, Y. Kim, J. Oh, and E. N. Olson
Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development
Development, July 15, 2010; 137(14): 2365 - 2374.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
L.-W. Tam, N. F. Wilson, and P. A. Lefebvre
A CDK-related kinase regulates the length and assembly of flagella in Chlamydomonas
J. Cell Biol., March 12, 2007; 176(6): 819 - 829.
[Abstract] [Full Text] [PDF]


Home page
MCPHome page
J. R. Zavzavadjian, S. Couture, W. S. Park, J. Whalen, S. Lyon, G. Lee, E. Fung, Q. Mi, J. Liu, E. Wall, et al.
The Alliance for Cellular Signaling Plasmid Collection: A Flexible Resource for Protein Localization Studies and Signaling Pathway Analysis
Mol. Cell. Proteomics, March 1, 2007; 6(3): 413 - 424.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
K. J. Palmer, J. E. Konkel, and D. J. Stephens
PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport
J. Cell Sci., September 1, 2005; 118(17): 3839 - 3847.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
R. Graeser, J. Gannon, R. Y. C. Poon, T. Dubois, A. Aitken, and T. Hunt
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells
J. Cell Sci., September 1, 2002; 115(17): 3479 - 3490.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
K. Cheng, Z. Li, W.-Y. Fu, J. H. Wang, A. K. Y. Fu, and N. Y. Ip
Pctaire1 Interacts with p35 and Is a Novel Substrate for Cdk5/p35
J. Biol. Chem., August 30, 2002; 277(35): 31988 - 31993.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
T. O'Neill, L. Giarratani, P. Chen, L. Iyer, C.-H. Lee, M. Bobiak, F. Kanai, B.-B. Zhou, J. H. Chung, and G. A. Rathbun
Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach
J. Biol. Chem., May 3, 2002; 277(18): 16102 - 16115.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
T. K. Ko, E. Kelly, and J. Pines
CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles
J. Cell Sci., July 15, 2001; 114(14): 2591 - 2603.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1999 by the American Association of Cancer Research.