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Cell Growth & Differentiation, Vol 1, Issue 8 375-382, Copyright © 1990 by American Association of Cancer Research


ARTICLES

Adenovirus 5 E1A represses muscle-specific enhancers and inhibits expression of the myogenic regulatory factor genes, MyoD1 and myogenin

SA Enkemann, SF Konieczny and EJ Taparowsky
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.

The early region 1A of adenoviruses encodes two multifunctional proteins that have varied effects on viral and host cell transcription. Expression of adenovirus 5 E1A in the mouse myogenic cell line 23A2 inhibits the differentiation of the cells and represses the expression of reporter genes controlled by several muscle-specific regulatory elements. In addition, differentiation-defective 23A2 E1A cells do not express MyoD1 or myogenin, the two myogenic regulatory factors that normally are expressed at high levels in this cell line. We conclude that E1A exerts a negative effect on the differentiation of skeletal muscle cells by interfering with the expression of myogenic regulatory factor genes that are essential for the transcriptional activation of the contractile protein gene set.


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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1990 by the American Association of Cancer Research.