CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, G. H.
Right arrow Articles by Roop, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, G. H.
Right arrow Articles by Roop, D. R.

Cell Growth & Differentiation, Vol 1, Issue 4 161-170, Copyright © 1990 by American Association of Cancer Research


ARTICLES

Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium

GH Smith, T Mehrel and DR Roop
Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Two keratins whose expression has been associated with proliferation (K14) and hyperproliferation (K6) in mouse epithelia were detected in normal, preneoplastic, and neoplastic mouse mammary tissues. K6 and K14 keratins were independently expressed in distinct epithelial cell populations in developing mammary anlage. K6 was confined to a small number of mammary epithelial cells associated with the growing end buds and among the proximal luminal epithelium, whereas K14 expression appeared in basally located fusiform cells that correspond to the location of mammary myoepithelial cells. This pattern was maintained in mature glands and through full functional differentiation with the exception that K6-positive cells were only rarely detectable. During lobuloalveolar growth in early pregnancy, K6 and K6/K14 coexpressing cells were observed among the luminal and suprabasal cells in the expanding lobular epithelium. This K6/K14 coexpressing epithelial subset persisted throughout pregnancy, lactation, and involution, albeit in much smaller numbers than observed in early pregnancy. Two patterns of K6 and K14 expression in preneoplastic and neoplastic lesions of mouse mammary glands were induced by various carcinogenic stimuli. In one, increased numbers of K6- or K14-positive cells were present in distinct cellular populations; in the other, coexpression of K6/K14 was found in a large subpopulation of both preneoplastic and neoplastic mammary epithelium. These observations suggest that expression of K6 and K14 keratins in the mouse mammary gland is associated with growth and expansion of specific mammary epithelial cell populations, and as such these keratins may be useful probes with which to identify mammary epithelium-specific primordial cells. In agreement with this possibility, K6/K14 expression was demonstrated within a distinct subset of morphologically distinct luminal mammary epithelial cells that have been reported to possess kinetic properties in vitro consistent with those expected of latent mammogenic stem cells.


This article has been cited by other articles:


Home page
DevelopmentHome page
L. E. Lindley, K. M. Curtis, A. Sanchez-Mejias, M. E. Rieger, D. J. Robbins, and K. J. Briegel
The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage
Development, March 1, 2015; 142(5): 893 - 904.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. M. Bussard, C. A. Boulanger, B. W. Booth, R. D. Bruno, and G. H. Smith
Reprogramming Human Cancer Cells in the Mouse Mammary Gland
Cancer Res., August 1, 2010; 70(15): 6336 - 6343.
[Abstract] [Full Text] [PDF]


Home page
Biochem. J.Home page
Y. T. Zhu, Y. Jia, L. Hu, C. Qi, M. K. Prasad, A. S. McCallion, and Y.-J. Zhu
Peroxisome-proliferator-activated receptor-binding protein (PBP) is essential for the growth of active Notch4-immortalized mammary epithelial cells by activating SOX10 expression
Biochem. J., January 15, 2010; 425(2): 435 - 444.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
B. Gu, P. Sun, Y. Yuan, R. C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rheaume, V. Bilanchone, J. M. Veltmaat, et al.
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation
J. Cell Biol., June 1, 2009; 185(5): 811 - 826.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. Fiaschi, B. Rozell, A. Bergstrom, and R. Toftgard
Development of Mammary Tumors by Conditional Expression of GLI1
Cancer Res., June 1, 2009; 69(11): 4810 - 4817.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
X.-Y. Wang, Y. Yin, H. Yuan, T. Sakamaki, H. Okano, and R. I. Glazer
Musashi1 Modulates Mammary Progenitor Cell Expansion through Proliferin-Mediated Activation of the Wnt and Notch Pathways
Mol. Cell. Biol., June 1, 2008; 28(11): 3589 - 3599.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
B. Tang, N. Yoo, M. Vu, M. Mamura, J.-S. Nam, A. Ooshima, Z. Du, P.-Y. Desprez, M. R. Anver, A. M. Michalowska, et al.
Transforming Growth Factor-{beta} Can Suppress Tumorigenesis through Effects on the Putative Cancer Stem or Early Progenitor Cell and Committed Progeny in a Breast Cancer Xenograft Model
Cancer Res., September 15, 2007; 67(18): 8643 - 8652.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
R. Villadsen, A. J. Fridriksdottir, L. Ronnov-Jessen, T. Gudjonsson, F. Rank, M. A. LaBarge, M. J. Bissell, and O. W. Petersen
Evidence for a stem cell hierarchy in the adult human breast
J. Cell Biol., April 9, 2007; 177(1): 87 - 101.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
W F Symmans, D J Fiterman, S K Anderson, M Ayers, R Rouzier, V Dunmire, J Stec, V Valero, N Sneige, C Albarracin, et al.
A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding
Endocr. Relat. Cancer, December 1, 2005; 12(4): 1059 - 1069.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
A. L. Welm, S. Kim, B. E. Welm, and J. M. Bishop
MET and MYC cooperate in mammary tumorigenesis
PNAS, March 22, 2005; 102(12): 4324 - 4329.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y. Li, B. Welm, K. Podsypanina, S. Huang, M. Chamorro, X. Zhang, T. Rowlands, M. Egeblad, P. Cowin, Z. Werb, et al.
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
PNAS, December 23, 2003; 100(26): 15853 - 15858.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
B. Risek, A. Pozzi, and N. B. Gilula
Modulation of gap junction expression during transient hyperplasia of rat epidermis
J. Cell Sci., May 1, 1998; 111(10): 1395 - 1404.
[Abstract] [PDF]


Home page
DevelopmentHome page
J. Wysolmerski, W. Philbrick, M. Dunbar, B Lanske, H Kronenberg, and A. Broadus
Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development
Development, January 4, 1998; 125(7): 1285 - 1294.
[Abstract] [PDF]


Home page
DevelopmentHome page
J. Wysolmerski, J. McCaughern-Carucci, A. Daifotis, A. Broadus, and W. Philbrick
Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development
Development, January 11, 1995; 121(11): 3539 - 3547.
[Abstract] [PDF]


Home page
DevelopmentHome page
G. Robinson, R. McKnight, G. Smith, and L Hennighausen
Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation
Development, January 7, 1995; 121(7): 2079 - 2090.
[Abstract] [PDF]


Home page
J. Cell Sci.Home page
R. Chammas, D. Taverna, N. Cella, C. Santos, and N. E. Hynes
Laminin and tenascin assembly and expression regulate HC11 mouse mammary cell differentiation
J. Cell Sci., April 1, 1994; 107(4): 1031 - 1040.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1990 by the American Association of Cancer Research.