CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cooper, M. J.
Right arrow Articles by Israel, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cooper, M. J.
Right arrow Articles by Israel, M. A.

Cell Growth & Differentiation, Vol 1, Issue 4 149-159, Copyright © 1990 by American Association of Cancer Research


ARTICLES

Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts

MJ Cooper, GM Hutchins, PS Cohen, LJ Helman, RJ Mennie and MA Israel
Molecular Genetics Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

We have examined the hypothesis that nonhematopoietic malignancies may contain cells corresponding to those which occur during the differentiation of tissue precursors. Neuroblastoma, an embryonal tumor of the adrenal medulla, was studied because of its well described ability to differentiate both in vivo and in vitro. We examined the expression of four genes during development of the human adrenal medulla: tyrosine hydroxylase, chromagranin A, pG2, and beta-2-microglobulin. The sequential expression of these genes by adrenal neuroblasts marks successive stages during maturation of the chromaffin lineage. We also observed a population of neuroblasts during adrenal medullary development that did not express any of these four genes, suggestive of adrenal medullary cells differentiating along nonchromaffin lineage(s). We then evaluated 27 neuroblastoma cell lines for the expression of these genes and found that 24 expressed chromaffin markers, with 19 of these mimicking the pattern of gene expression found during development. Three cell lines did not express tyrosine hydroxylase, chromogranin A, or pG2, consistent with either a very undifferentiated neural crest cell or maturation along a nonchromaffin lineage. These data indicate that neuroblastoma tumor cells correspond to adrenal neuroblasts arrested during morphogenesis of the adrenal medulla and raise the possibility that malignant transformation of cells at different stages of tissue maturation may contribute to the diversity that characterizes tumors of solid tissues.


This article has been cited by other articles:


Home page
haematolHome page
B. Mirshekar-Syahkal, E. Haak, G. M. Kimber, K. van Leusden, K. Harvey, J. O'Rourke, J. Laborda, S. R. Bauer, M. F. T. R. de Bruijn, A. C. Ferguson-Smith, et al.
Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells
Haematologica, February 1, 2013; 98(2): 163 - 171.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
E. R. Lawlor and C. J. Thiele
Epigenetic Changes in Pediatric Solid Tumors: Promising New Targets
Clin. Cancer Res., May 15, 2012; 18(10): 2768 - 2779.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. J. Rorie, V. D. Thomas, P. Chen, H. H. Pierce, J. P. O'Bryan, and B. E. Weissman
The Ews/Fli-1 Fusion Gene Switches the Differentiation Program of Neuroblastomas to Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors
Cancer Res., February 15, 2004; 64(4): 1266 - 1277.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
F. HEDBORG, E. ULLERAS, L. GRIMELIUS, E. WASSBERG, P. H MAXWELL, B. HERO, F. BERTHOLD, F. SCHILLING, D. HARMS, B. SANDSTEDT, et al.
Evidence for hypoxia-induced neuronal-to-chromaffin metaplasia in neuroblastoma
FASEB J, April 1, 2003; 17(6): 598 - 609.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
D. S. Middlemas, B. K. Kihl, J. Zhou, and X. Zhu
Brain-derived Neurotrophic Factor Promotes Survival and Chemoprotection of Human Neuroblastoma Cells
J. Biol. Chem., June 4, 1999; 274(23): 16451 - 16460.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
S. H. Hahm and L. E. Eiden
Five Discrete Cis-active Domains Direct Cell Type-specific Transcription of the Vasoactive Intestinal Peptide (VIP) Gene
J. Biol. Chem., July 3, 1998; 273(27): 17086 - 17094.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
B. B. Chang, S. P. Persengiev, J. G. de Diego, M. P. Sacristan, D. M. Zanca, and D. L. Kilpatrick
Proximal Promoter Sequences Mediate Cell-specific and Elevated Expression of the Favorable Prognosis Marker TrkA in Human Neuroblastoma Cells
J. Biol. Chem., January 2, 1998; 273(1): 39 - 44.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1990 by the American Association of Cancer Research.