CG&D
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rojas, M.
Right arrow Articles by Stanners, C. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rojas, M.
Right arrow Articles by Stanners, C. P.

Cell Growth & Differentiation, Vol 1, Issue 11 527-533, Copyright © 1990 by American Association of Cancer Research


ARTICLES

Biliary glycoprotein, a member of the immunoglobulin supergene family, functions in vitro as a Ca2(+)-dependent intercellular adhesion molecule

M Rojas, A Fuks and CP Stanners
Cancer Centre, McGill University, Montreal, Quebec, Canada.

Intercellular adhesion molecules can be classified as Ca2+ dependent or Ca2+ independent. This classification has significant functional implications regarding cellular interactions. The best characterized Ca2(+)-dependent adhesion molecules, such as L-CAM or E-cadherin, belong to the family of closely related cell surface molecules called cadherins. On the other hand, those immunoglobulin supergene family members which function as adhesion molecules, such as neural cell adhesion molecule, have been found to be Ca2+ independent. In agreement with this generalization, we have recently shown that carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA), two closely related members of the CEA family, a subset of the immunoglobulin supergene family, function in vitro as Ca2(+)-independent adhesion molecules. In contrast, we show here that transfectants of a third member of the CEA family, biliary glycoprotein (BGP), also aggregate homotypically in suspension but require Ca2+ for aggregation. In addition, like the cadherins and unlike CEA or NCA or other adhesion molecules of the immunoglobulin supergene family, BGP transfectant aggregation requires physiological temperatures. Two forms of BGP, with three and two immunoglobulin C2-set domains, show Ca2(+)- and temperature-dependent adhesion, so that these properties do not reside in the third C2-set domain. The significance of this expression in the range of functional properties of the immunoglobulin supergene family and its CEA subset is discussed.


This article has been cited by other articles:


Home page
J Biol ChemHome page
P. C. Patel, H. S. W. Lee, A. Y. K. Ming, A. Rath, C. M. Deber, C. M. Yip, J. V. Rocheleau, and S. D. Gray-Owen
Inside-out Signaling Promotes Dynamic Changes in the Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 (CEACAM1) Oligomeric State to Control Its Cell Adhesion Properties
J. Biol. Chem., October 11, 2013; 288(41): 29654 - 29669.
[Abstract] [Full Text] [PDF]


Home page
Physiol. GenomicsHome page
M. Donowitz, S. Singh, P. Singh, F. F. Salahuddin, Y. Chen, M. Chakraborty, R. Murtazina, M. Gucek, R. N. Cole, N. C. Zachos, et al.
Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles
Physiol Genomics, November 1, 2010; 42A(3): 200 - 210.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
E. O. Lobo, Z. Zhang, and J. E. Shively
Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner
J. Leukoc. Biol., August 1, 2009; 86(2): 205 - 218.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
T. B. Nicholson and C. P. Stanners
Identification of a novel functional specificity signal within the GPI anchor signal sequence of carcinoembryonic antigen
J. Cell Biol., April 23, 2007; 177(2): 211 - 218.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
C. Fuse, Y. Ishida, T. Hikita, T. Asai, and N. Oku
Junctional Adhesion Molecule-C Promotes Metastatic Potential of HT1080 Human Fibrosarcoma
J. Biol. Chem., March 16, 2007; 282(11): 8276 - 8283.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
K. Reiss, T. Maretzky, I. G. Haas, M. Schulte, A. Ludwig, M. Frank, and P. Saftig
Regulated ADAM10-dependent Ectodomain Shedding of {gamma}-Protocadherin C3 Modulates Cell-Cell Adhesion
J. Biol. Chem., August 4, 2006; 281(31): 21735 - 21744.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
N. Kilic, L. Oliveira-Ferrer, J.-H. Wurmbach, S. Loges, F. Chalajour, S. N. Vahid, J. Weil, M. Fernando, and S. Ergun
Pro-angiogenic Signaling by the Endothelial Presence of CEACAM1
J. Biol. Chem., January 21, 2005; 280(3): 2361 - 2369.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. Oliveira-Ferrer, D. Tilki, G. Ziegeler, J. Hauschild, S. Loges, S. Irmak, E. Kilic, H. Huland, M. Friedrich, and S. Ergun
Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Angiogenesis and Invasion of Human Urinary Bladder Cancer
Cancer Res., December 15, 2004; 64(24): 8932 - 8938.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
G. Markel, R. Gruda, H. Achdout, G. Katz, M. Nechama, R. S. Blumberg, R. Kammerer, W. Zimmermann, and O. Mandelboim
The Critical Role of Residues 43R and 44Q of Carcinoembryonic Antigen Cell Adhesion Molecules-1 in the Protection from Killing by Human NK Cells
J. Immunol., September 15, 2004; 173(6): 3732 - 3739.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
G. Markel, H. Mussaffi, K.-L. Ling, M. Salio, S. Gadola, G. Steuer, H. Blau, H. Achdout, M. de Miguel, T. Gonen-Gross, et al.
The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients
Blood, March 1, 2004; 103(5): 1770 - 1778.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
F. Naghibalhossaini and C. P. Stanners
Minimal mutations are required to effect a radical change in function in CEA family members of the Ig superfamily
J. Cell Sci., February 15, 2004; 117(5): 761 - 769.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
P. Jantscheff, L. Terracciano, A. Lowy, K. Glatz-Krieger, F. Grunert, B. Micheel, J. Brummer, U. Laffer, U. Metzger, R. Herrmann, et al.
Expression of CEACAM6 in Resectable Colorectal Cancer: A Factor of Independent Prognostic Significance
J. Clin. Oncol., October 1, 2003; 21(19): 3638 - 3646.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
W. Sienel, S. Dango, U. Woelfle, A. Morresi-Hauf, C. Wagener, J. Brummer, W. Mutschler, B. Passlick, and K. Pantel
Elevated Expression of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 Promotes Progression of Non-Small Cell Lung Cancer
Clin. Cancer Res., June 1, 2003; 9(6): 2260 - 2266.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. Kirshner, C.-J. Chen, P. Liu, J. Huang, and J. E. Shively
CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture
PNAS, January 21, 2003; 100(2): 521 - 526.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
M. Kuroki, H. Abe, T. Imakiirei, S. Liao, H. Uchida, Y. Yamauchi, S. Oikawa, and M. Kuroki
Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8
J. Leukoc. Biol., October 1, 2001; 70(4): 543 - 550.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
S. M. Watt, A. M. Teixeira, G.-Q. Zhou, R. Doyonnas, Y. Zhang, F. Grunert, R. S. Blumberg, M. Kuroki, K. M. Skubitz, and P. A. Bates
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site
Blood, September 1, 2001; 98(5): 1469 - 1479.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
R. A. Gupta, J. A. Brockman, P. Sarraf, T. M. Willson, and R. N. DuBois
Target Genes of Peroxisome Proliferator-activated Receptor {gamma} in Colorectal Cancer Cells
J. Biol. Chem., August 10, 2001; 276(32): 29681 - 29687.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
T. Chen, W. Zimmermann, J. Parker, I. Chen, A. Maeda, and S. Bolland
Biliary glycoprotein (BGPa, CD66a, CEACAM1) mediates inhibitory signals
J. Leukoc. Biol., August 1, 2001; 70(2): 335 - 340.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
R. Kammerer, D. Stober, B. B. Singer, B. Obrink, and J. Reimann
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation
J. Immunol., June 1, 2001; 166(11): 6537 - 6544.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
R. A. Screaton, L. DeMarte, P. Draber, and C. P. Stanners
The Specificity for the Differentiation Blocking Activity of Carcinoembryonic Antigen Resides in Its Glycophosphatidyl-Inositol Anchor
J. Cell Biol., August 7, 2000; 150(3): 613 - 626.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. M. Skubitz, K. D. Campbell, and A. P. N. Skubitz
Synthetic Peptides of CD66a Stimulate Neutrophil Adhesion to Endothelial Cells
J. Immunol., April 15, 2000; 164(8): 4257 - 4264.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
J. Huang, J. D. Hardy, Y. Sun, and J. E. Shively
Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F
J. Cell Sci., December 1, 1999; 112(23): 4193 - 4205.
[Abstract] [PDF]


Home page
J Biol ChemHome page
M. Huber, L. Izzi, P. Grondin, C. Houde, T. Kunath, A. Veillette, and N. Beauchemin
The Carboxyl-terminal Region of Biliary Glycoprotein Controls Its Tyrosine Phosphorylation and Association with Protein-tyrosine Phosphatases SHP-1 and SHP-2 in Epithelial Cells
J. Biol. Chem., January 1, 1999; 274(1): 335 - 344.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
J. Famiglietti, J. Sun, H. M. DeLisser, and S. M. Albelda
Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity
J. Cell Biol., September 22, 1997; 138(6): 1425 - 1435.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
T. Chen, F. Grunert, A. Medina-Marino, and E. C. Gotschlich
Several Carcinoembryonic Antigens (CD66) Serve as Receptors for Gonococcal Opacity Proteins
J. Exp. Med., May 5, 1997; 185(9): 1557 - 1564.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
T. A. Quill and D. L. Garbers
Sperad Is a Novel Sperm-specific Plasma Membrane Protein Homologous to a Family of Cell Adhesion Proteins
J. Biol. Chem., December 27, 1996; 271(52): 33509 - 33514.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
H.-C. Yan, H. S. Baldwin, J. Sun, C. A. Buck, S. M. Albelda, and H. M. DeLisser
Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1)
J. Biol. Chem., October 6, 1995; 270(40): 23672 - 23680.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
I. Hunter, M. Lindh, and B. Obrink
Differential regulation of C-CAM isoforms in epithelial cells
J. Cell Sci., May 1, 1994; 107(5): 1205 - 1216.
[Abstract] [PDF]


Home page
J Biol ChemHome page
R. A. Gupta, J. A. Brockman, P. Sarraf, T. M. Willson, and R. N. DuBois
Target Genes of Peroxisome Proliferator-activated Receptor {gamma} in Colorectal Cancer Cells
J. Biol. Chem., August 10, 2001; 276(32): 29681 - 29687.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 1990 by the American Association of Cancer Research.