Fig. 7. Cells expressing farnesylated RhoA are still sensitive to growth inhibition by inhibition of GGTaseI. Cultures of NIH 3T3 cells stably expressing RhoA(63L)-WT or RhoA(63L)-CVLS were incubated with growth medium supplemented with 3 or 10 µM GGTI-2166. Cell number was determined on days 3, 5, 6, 8, 10, and 12, with data shown for day 12, are the average of duplicate dishes and are representative of three independent experiments; bars, SE.