Click on image to view larger version.



Fig. 5. Effects of bryostatin-1 + GM-CSF on primary AML samples. Isolated AML blasts were incubated for 120 h in the absence (Control) or presence of bryostatin-1 (10-8 M) with or without GM-CSF (200 units/ml) and assayed for CD15 expression (A) and clonogenic growth (B). Results represent the means for the seven patient specimens; bars, SE. P = 0.002 was determined by ANOVA for the comparison of all treatment groups for both CD15 expression (A) and clonogenic growth (B).