Table 1 HLA-DR and CIITA expression and CIITA promoter III and promoter IV element functions in melanoma cell lines

Cell line HLA-DR by surface staininga CIITA promoter III activation CIITA promoter IV activation Promoter III ARE-1 function Promoter III Oct-1 repression Promoter IV IRF-E function

WM9 + + + + - +
Mel1102 + + + + - +
Mel1286 - - - + + -
Mel1379 - - - - - -
Mel1479 - - - - - -
NHM4528 (normal melanocytes) Inducibleb Inducibleb Inducibleb + - +

a Data not shown.

b Inducible by IFN-{gamma}.