Table 1 Cdk5 substrates and their subcellular affiliations

Known or potential substrates of Cdk5 are listed at the left of the table. A (+) indicates a published relationship of that particular substrate to those structures. A (-) indicates that no clear published information linking the substrate to the structure was found. Many of the interactions are referenced in the text or in review articles cited in the text.


Cdk5 substrate Actin Microtubules Synapse Growth cone
NFH + + - -
Pak1 + - - +
Src + + + +
mDab1 + - - +
Cables + - - +
Nudel - + - +
ß-catenin - + + +
Tau - + - -
Map2 - + - -
Map1b - + - -
Synapsin-1 - - + +
Amphiphysin-1 + - + +
Munc-18 - - + +
DARPP-32 - - + +
PP1 inhibitor - - + +
ß-APP - - + +
Retinal cGMP PDE - - - -
ErbB - - + -