Fig. 1. Induction of apoptosis by CDDO. U-937 and HL-60 cells were treated with 5 µM CDDO and harvested at 12 and 24 h. A, DNA fragmentation was monitored by electrophoresis in 2% agarose gels. B, total cell lysates were analyzed by immunoblotting with anti-PARP antibody. FL, full length; CF, cleaned fragment.