Fig. 1. The effects of activators of PPARs on the viability of human prostatic adenocarcinoma cell lines, DU145, PC-3, and LNCaP. Cells were incubated with 0.01–100 µM linoleic acid (an activator of PPAR-ß), ETYA (an activator of PPAR-{alpha}), and prostaglandin E2 (an inert activator for PPARs); 1–10 µM, 15d-PGJ2; 5–100 µM EPA and DHA; and 2–20 µM, ciglitazone (activators of PPAR-{gamma}); or, vehicle controls (column 0) for 6 days. Viable cells were measured by MTS assay and expressed as a percentage of controls (n = 4–6); bars, SD.