Table 1 Cell cycle distribution of growth factor-treated NIH 3T3 cells in the presence and absence of PD 098059a

Control TGF-ß1

FGF-2

PDGF

-PD98059 +PD98059 -PD98059 +PD98059 -PD98059 +PD98059

G1 85 81 85 77 80 76 83
S 2 3 3 14 5 13 5
G2/M 13 16 12 9 16 11 12

a Starved NIH 3T3 cells were treated with TGF-ß1 (250 pM), FGF-2 (7 ng/ml), or PDGF (10 ng/ml) in the presence or absence of 50 µM PD 098059 for 12 h followed by flow cytometry.