Fig. 7. Effects of synthetic retinoids on the morphology (A) and growth (B) of the stably transfected P388D1 cells overexpressing the M6P/IGF2R. Both the morphological data and the cell number shown were obtained at 48 h after treatment of the cells with RA and/or synthetic retinoids. (a) control; (b) 0.25 µM RA; (c) 1 µM TTNPB (a potent RAR agonist); (d) 2 µM AGN193109 (a potent RAR antagonist); (e) 0.25 µM RA + 2 µM AGN193109. Each point, the mean of three separate experiments (n = 3; *, P < 0.05 versus control).