Fig. 6. Effects of RA analogues on the morphology (A) and growth (B) of the stably transfected P388D1 cells overexpressing the M6P/IGF2R. Both the morphological data and the cell number shown were obtained at 48 h after treatment of the cells with 1 µM of all-trans-RA, retinol, or retinol acetete. Each point, the mean of three separate experiments (n = 3; *, P < 0.05 versus control). a, control (Cont.); b, RA (RA); c, retinol (ROH); d, retinol acetate (ROHA).